As a result of global migration, nurses are caring for patients in increasingly diverse cultural and linguistic settings. Intercultural nursing requires nurses to care for patients as unique individuals while considering their cultural needs. Being able to communicate effectively with patients from various cultures is crucial for understanding and for optimal delivery of patient care. Communication must be considered in the context of overall care; therefore, this article describes important concepts underpinning appropriate intercultural care. It provides a guide to effective intercultural communication by discussing three main areas: cultural knowledge, attitudes and feelings, and communication skills. These are the essential areas that nurses can reflect on, and develop and apply in intercultural communication with patients and their families.