Evidence on the incidence of child sexual abuse (CSA) indicates it is a global epidemic that adversely affects the short- and long-term physical and mental health outcomes of those affected. Learning from safeguarding practice reviews suggests healthcare professionals (HCPs) are in a unique position to identify and intervene when they suspect CSA. However, research suggests that HCPs have insufficient knowledge to identify CSA, intervene and manage the individual’s care. This article reports the findings of a systematic literature review that explored HCAs’ knowledge of how to identify and respond to CSA. The findings from the published research on this topic indicate that HCAs have limited knowledge and confidence, which can prevent them from fulfilling their mandatory safeguarding roles. The literature review emphasises the need to improve training to ensure better health outcomes for children and young people who have been sexually abused.