Non-Hodgkin’s lymphoma is a heterogeneous group of lymphoproliferative malignancies with differing patterns of behaviour and responses to treatment. Chemotherapy, radiotherapy and stem cell transplantation are the main treatment modalities, but targeted therapies such as monoclonal antibodies are improving survival. The complex nature of the disease, and different treatment pathways, mean that nurses working in this area need in-depth knowledge to provide patient education, continuity of care and advice on current treatment options, as well as to ensure an optimal patient journey.