There is growing evidence to suggest that men are at increased risk of premature death from a broad range of health conditions. With the government’s mandate to reduce premature death, it is necessary to have an understanding of the health challenges faced by men. This article provides an overview of mortality data for men and women aged 15-64, with a focus on those aged 15-54, in England and Wales during 2011. Mortality data are viewed in relation to the main reasons for premature death in the male population. Initiatives aimed at addressing the health and social care needs of men are identified to raise awareness of the importance of targeting this population to reduce premature mortality.