Genomic testing can support the identification of abnormalities and developmental changes in patients’ genes. Advances in technology and national infrastructure have led to increased access to genomic testing that can inform decisions about patient care. Care pathways are becoming increasingly personalised based on genomic information and nursing practice has evolved in line with these developments. All nurses should have sufficient knowledge about genomics to perform their role effectively. This article aims to enhance nurses’ understanding of genomics and explains its benefits in healthcare practice.