All nurses and healthcare workers have a vital role in caring for people with a life-limiting prognosis. The importance of this role was accentuated during the widespread loss of life resulting from the coronavirus disease 2019 (COVID-19) pandemic. This article revisits the crucial role of nurses in the care of people with advanced disease, while outlining how nurses can provide evidence-based palliative and end of life care. The author explores some of the essential elements of symptom management in advanced disease and presents a series of short case studies to support nurses’ critical reflection.