The vital role of nurses in the delivery of safe and effective patient care is widely recognised. However, due to the significant stress associated with the role and its responsibilities, including ongoing challenges in healthcare organisations, there are high burnout rates among nurses. Burnout is defined as unmanaged workplace stress that causes physical, mental and emotional fatigue, and it has been recognised as an occupational phenomenon. It is essential to identify the early warning signs of nurse burnout so that it can be addressed in a timely manner. Resilience has an important role in supporting nurses to cope with and adapt to adverse experiences, thereby supporting them to improve their health and well-being and subsequently to provide high-quality patient care. This article outlines the support and strategies that nurse managers and organisational leaders can put in place to manage burnout and develop resilience among nurses.