This article explores the experiences of South Thames Retrieval Service (STRS) retrieval nurse practitioners in providing inter-hospital transfers of critically ill babies and children during the coronavirus disease 2019 (COVID-19) pandemic. As well as its usual cohort of patients, the STRS also transferred critically ill and ventilated adults. The authors present a comparative analysis of pre-pandemic and pandemic retrievals over two six-week periods, one year apart. In the first period, from December 2019 to the end of January 2020, STRS retrieval nurse practitioners transported 47 critically ill children. One year later, during the second wave of the COVID-19 pandemic, STRS retrieval nurse practitioners transported 50 critically ill children and 26 critically ill adults with COVID-19 and a premature baby who was a COVID-19 contact. The latter two groups are not usually transported by the service. All of the patients retrieved by the STRS team during the COVID-19 pandemic were safely transported. This initiative demonstrated how nurses worked flexibly during the pandemic within the limits of their professional competence.