Background The actor-partner interdependence model (APIM) is widely used to study people with close relationships, such as patients and their partners. However, the complexity of the model has made it difficult to implement in nursing research.

Aim To provide a simplified description of the model, highlight the key assumptions of dyadic data and examine the related challenges in using statistical techniques.

Discussion Researchers must address certain assumptions when analysing dyadic data. They should select statistical techniques based on these assumptions and the research questions.

Conclusion The AIPM is the most appropriate approach for studying dyads. This article may help to create a more consistent framework for nurse researchers who incorporate the APIM into their studies.

Implications for practice This article will help in implementing APIM in dyad-focused nursing studies by addressing key assumptions of the model and using appropriate statistical techniques.