People with Down’s syndrome are more likely to have additional health complications than the general population, including coeliac disease. It is important to monitor people for signs and symptoms of the condition and complete further assessments as required. A gluten-free diet is best practice in management of coeliac disease and this article provides information on how to support people with Down’s syndrome to adhere to this diet. The article also describes the increased incidence of coeliac disease in people with Down’s syndrome, how support staff and carers can monitor for signs or symptoms of the condition, and how to support early identification through screening. It also discusses treatment of coeliac disease and the monitoring required for improved health outcomes.