Nursing support during treatment of multiple myeloma with proteasome inhibitors
Intended for healthcare professionals
Evidence and practice    

Nursing support during treatment of multiple myeloma with proteasome inhibitors

Erik Aerts Nurse manager, President of Haematology Nurses and Healthcare Professionals Group, Department of Internal Medicine, Hematology, University Hospital Zurich, Zurich, Switzerland
Zsolt Szabo Regional development medical director, Amgen (Europe) GmbH, Zug, Switzerland
Matthias Hellberg-Naegele Nursing expert and advanced practice nurse for patients with multiple myeloma, University Medical Center Freiburg, Freiburg, Germany

In the past two years proteasome inhibitors have risen in prominence reflecting the recent approval of two new agents, carfilzomib and ixazomib. This means there are three different agents of this class available for the treatment of multiple myeloma. These agents are highly effective and suitable for use in combination with other agents, however each has a different route of administration and an individual toxicity profile. Optimal patient management is required to use these agents to their full potential.

Nurses are instrumental in educating patients about these treatment options and managing their individual toxicities during treatment. They also play a crucial part in supporting ongoing communication between patients and the multidisciplinary team. To succeed in this role, nurses require a thorough understanding of evidence-based symptom-management programmes, and a good awareness of the efficacy and safety profiles of newer drugs. Time should be set aside for nurses to be educated and trained appropriately on topics identified in this review, and initiatives such as local myeloma learning programmes may be useful. This article discusses the central role of nurses in the management of proteasome inhibitors for the treatment of patients with multiple myeloma.

Cancer Nursing Practice. doi: 10.7748/cnp.2018.e1488


Aerts E, Szabo Z, Hellberg-Naegele M (2018) Nursing support during treatment of multiple myeloma with proteasome inhibitors. Cancer Nursing Practice. doi: 10.7748/cnp.2018.e1488

Peer review

This article has been subject to external double-blind review and checked for plagiarism using automated software


Conflict of interest

Erik Aerts has no conflicts of interest; Matthias Hellberg-Naegele has participated in an Amgen carfilzomib advisory board; Zsolt Szabo is an employee of Amgen and holds Amgen stocks


Medical writing support was provided by Liz Hartfield PhD and Kim Allcott PhD from Oxford PharmaGenesis, Oxford, UK, and funded by Amgen (Europe) GmbH. Editorial support was provided by Emma Booth, Carine Thual and Sarah Petrig of Amgen (Europe) GmbH

Published online: 05 July 2018

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