Leg ulcers are wounds or open sores, often chronic in nature (long-lasting and non-healing), which cause damage to the skin. Appropriate management of chronic venous leg ulcers is essential to prevent further deterioration of the wound, improve patients’ quality of life and reduce any healthcare costs associated with treating complications of such ulcers, including infection. However, management of leg ulcers can be challenging, particularly in patients who do not adhere to treatment regimens, cannot tolerate compression therapy, or have increased pain and infection. This article aims to identify best practice in the management of venous leg ulcers.