This article, the first in a series written by pain nurse specialists, provides an overview of the nature, causes and structured management of acute, chronic and neuropathic pain. The differences between nociceptive and neuropathic pain, and treatment options are identified. The pain management service’s roles are described in the context that a person’s experience of pain is the result of biological, psychological and social factors. Future articles will explore the physiology and pharmacology of pain, how patients express pain and interventions for acute and chronic pain. They will also provide guidance on managing pain in challenging circumstances.