Venous thromboembolism (VTE) occurs more frequently in older people. For those nursing older people in a variety of settings, knowledge of VTE prevention, diagnosis and treatment is essential. This article discusses simple, practical measures that can be used to reduce the risk of VTE, including good hydration and promotion of mobilisation. It also discusses how a VTE forms, the signs and symptoms, and the methods used to diagnose and treat VTE. In recent years new drugs have been licensed to treat patients with VTE called direct oral anticoagulants. This article explores recent evidence and important considerations for their use in treatment of VTE.