NHS England has committed to reduce the amount of psychotropic medicines being prescribed for people with learning disabilities. Studies suggest the numbers of people with learning disabilities prescribed psychotropic medicines is far higher than numbers with documented mental health diagnoses, for which such medicines should be prescribed. This article examines the reasons why medication is prescribed, best practice, the side effects and the issues that are involved with the withdrawal of psychotropic medicines, in particular antipsychotics, in people with learning disabilities. Learning disability nurses are well placed to review and assist with the withdrawal of antipsychotic medication; they are an integral part of the challenge to reduce prescribing of antipsychotic medicines for people with learning disabilities. They also offer a vital link between healthcare professionals in primary and secondary care.