Antimalarial drug overdose: clinical features and management
Clinical Previous     Next

Antimalarial drug overdose: clinical features and management

Sarah McCrea Information Officer, National Poisons Information Service (London)

As part of the ongoing series on poisoning, Sarah McCrea describes the features and management of antimalarial drug overdose

Malaria is caused by infection with protozoan parasites of the Plasmodia genus; the four species which are important in human disease are Plasmodium falciparum, P. vivax, P. ovale and P. malariae. The parasites (known as sporozoites at this stage) enter the bloodstream through the bite of a female Anopheles mosquito. They migrate to the liver, where they infect hepatocytes. They then undergo schizogony (divide and multiply) for a couple of weeks. The infected cells then rupture, releasing parasites which invade erythrocytes, and, again mature, divide and multiply until eventually the erythrocyte ruptures, releasing fresh parasites. Repeated cycles of this process of invasion and rupture of erythrocytes are responsible for the cyclical clinical symptoms seen with malaria (chills, fever, rigors). Other symptoms common to all types of malaria include anaemia, jaundice, splenomegaly and hepatomegaly. In P. vivax or P. ovale infection some of the parasites may persist in the hepatic stage for years, and cause relapses. P. falciparum, responsible for the most severe form of malaria, can be fatal, particularly if cerebral malaria develops.

Emergency Nurse. 9, 1, 20-25. doi: 10.7748/en2001.04.9.1.20.c1352

Want to read more?

Subscribe for unlimited access

Try 1 month’s access for just £1 and get:

Your subscription package includes:
  • Full access to the website and the online archive
  • Bi-monthly digital edition
  • RCNi Portfolio and interactive CPD quizzes
  • RCNi Learning with 200+ evidence-based modules
  • 10 articles a month from any other RCNi journal
Subscribe
Already subscribed? Log in

Alternatively, you can purchase access to this article for the next seven days. Buy now

Or