Healthcare is continuously evolving to adapt to a changing world and nurses have an essential role in introducing innovative practice as part of continuous quality improvement (QI). For nurses who want to put forward a proposal for change, drafting a clear and convincing business case is a useful skill to have. This article provides advice to nurses who are new to QI on how to draft a business case to support small-scale change in their practice setting. It describes the steps involved, which encompass identifying the issue and its root causes, describing the context, outlining the solution, addressing the financial aspects and detailing plans for implementation and evaluation.